Quality of life of patients treated surgically for head and neck cancer

The quality of survival of 48 patients treated surgically for head and neck cancer was assessed using a problem-orientated self-administered questionnaire. The questionnaire was based on the European Organization for Research into the Treatment of Cancer (EORTC) core questionnaire to which a specific head and neck module was added. The following domains were studied: pain, fatigue, physical symptoms (gastrointestinal and 'other'), functional activity, psychological symptoms, overall physical condition and overall quality of life. For the analysis, five groups of patients were considered: laryngectomy (n = 15), pharyngolaryngoesophagectomy (n = 5), craniofacial procedure (n = 11), 'other operations' (n = 9) and patients with disease recurrence (n = 8). Each group identified different problem areas. Laryngectomees and 'other operation' patients reported relatively few problems, whereas patients with disease recurrence described difficulties in all of the domains examined. Symptoms of fatigue were common. Information collected in this way may facilitate improved rehabilitation and thus better quality of survival

A psychometric evaluation of the Female Sexual Function Index in women treated for breast cancer.

BACKGROUND: We aimed to determine the psychometric properties and factor structure of the 19-item Female Sexual Function Index (FSFI) in 132 sexually active women previously treated for breast cancer. METHODS: Confirmatory factor analysis explored three models: (a) second-order six-factor, (b) six-factor, and (c) five-factor models combining the desire and arousal subscales. RESULTS: Results revealed excellent reliability for the total score (Cronbach's α = 0.94), and domain scores (all Cronbach's αs > 0.90), and good convergent and discriminant validity. The six-factor model provided the best fit of the models assessed, but a marginal overall fit (Tucker-Lewis index = 0.91, comparative fit index = 0.93, root mean square error of approximation = 0.09). Exploratory factor analyses (EFA) supported a four-factor structure, revealing an arousal/orgasm factor alongside the original pain, lubrication, and satisfaction domains. CONCLUSION: The arousal/orgasm factor suggests a "sexual response" construct, potentially arising from an underlying latent factor involving physical and mental stimulation in conceptualizations of arousal and orgasm in women treated for breast cancer. Finally, the EFA failed to capture an underlying desire factor, potentially due to measurement error associated with the small number of items (two) in this domain. Despite evidence that the FSFI has sound psychometric properties, our results suggest that the current conceptualizations of the FSFI might not accurately represent sexual functioning in women previously treated for breast cancer. Further research is required to elucidate the factors that influence desire, arousal, and orgasm in sexually active women in this population, and the reasons underlying sexual inactivity. Practical and theoretical implications for FSFI use in this population are discussed

Cultural modulation of face and gaze scanning in young children

Previous research has demonstrated that the way human adults look at others’ faces is modulated by their cultural background, but very little is known about how such a culture-specific pattern of face gaze develops. The current study investigated the role of cultural background on the development of face scanning in young children between the ages of 1 and 7 years, and its modulation by the eye gaze direction of the face. British and Japanese participants’ eye movements were recorded while they observed faces moving their eyes towards or away from the participants. British children fixated more on the mouth whereas Japanese children fixated more on the eyes, replicating the results with adult participants. No cultural differences were observed in the differential responses to direct and averted gaze. The results suggest that different patterns of face scanning exist between different cultures from the first years of life, but differential scanning of direct and averted gaze associated with different cultural norms develop later in life

Clastic injectites, internal structures and flow regime during injection: The Sea Lion Injectite System, North Falkland Basin

This paper details and describes a suite of 143 sub‐seismic‐scale clastic injectites encountered within the early Cretaceous, early post‐rift of the deep‐lacustrine North Falkland Basin. The injectites, referred to here as the Sea Lion Injectite System, are encountered below, above and in between the hydrocarbon‐bearing, deep‐lacustrine turbidite sandstones of the Bleaker 15, Sea Lion North, Sea Lion, Casper and Beverley fans. Sedimentary structures are documented within the injectites including: planar laminations, mud‐clast imbrication and clast alignment. Clasts align along centimetre‐scale foresets formed through ripple‐scale bedform migration in a hydraulically‐open fracture. The style of flow within the injectite system is interpreted as initially through fluid turbulence during an open fracture phase, which was followed by a later stage where laminar flow dominated, most likely during the closing phase of the fracture system. The host rocks display evidence for ductile deformation, which along with ptygmatic folding of dykes and internally injected mud‐clasts, suggests a period of injection into relatively uncompacted sediments. Evidence for brittle fracturing, in the form of stepped margins may be indicative of a separate phase of emplacement into more‐compacted sediments. This variability in deformation styles is related to multi‐phased injection episodes into host strata at different stages of consolidation and lithification at shallow burial depths. Injectites have been identified in four stratigraphic groupings: above the Bleaker 15 Fan and within/above the Sea Lion North Fan; within the hydrocarbon‐bearing Sea Lion Fan; overlying the Sea Lion Fan; and above/below the hydrocarbon‐bearing Casper and Beverley fans. This spatial association with the hydrocarbon‐bearing fans of the North Falkland Basin is important, considering the ability of injectite networks to form effective fluid‐flow conduits in the subsurface. Consequently, the findings of this study will improve the characterization of sub‐seismic scale injectites (and therefore fluid conduits) within otherwise impermeable strata

Stellar Property Statistics of Massive Halos from Cosmological Hydrodynamics Simulations: Common Kernel Shapes

We study stellar property statistics, including satellite galaxy occupation, of massive halo populations realized by three cosmological hydrodynamics simulations: BAHAMAS + MACSIS, TNG300 of the IllustrisTNG suite, and Magneticum Pathfinder. The simulations incorporate independent sub-grid methods for astrophysical processes with spatial resolutions ranging from $1.5$ to $6$ kpc, and each generates samples of $1000$ or more halos with $M_{\rm halo}> 10^{13.5} M_{\odot}$ at redshift $z=0$. Applying localized, linear regression (LLR), we extract halo mass-conditioned statistics (normalizations, slopes, and intrinsic covariance) for a three-element stellar property vector consisting of: i) $N_{sat}$, the number of satellite galaxies with stellar mass, $M_{\star, \rm sat} > 10^{10} M_{\odot}$ within radius $R_{200c}$ of the halo; ii) $M_{\star,\rm tot}$, the total stellar mass within that radius, and; iii) $M_{\star,\rm BCG}$, the gravitationally-bound stellar mass of the central galaxy within a $100 \, \rm kpc$ radius. Scaling parameters for the three properties with halo mass show mild differences among the simulations, in part due to numerical resolution, but there is qualitative agreement on property correlations, with halos having smaller than average central galaxies tending to also have smaller total stellar mass and a larger number of satellite galaxies. Marginalizing over total halo mass, we find the satellite galaxy kernel, $p(\ln N_{sat}\,|\,M_{\rm halo},z)$ to be consistently skewed left, with skewness parameter $\gamma = -0.91 \pm 0.02$, while that of $\ln M_{\star,\rm tot}$ is closer to log-normal, in all three simulations. The highest resolution simulations find $\gamma \simeq -0.8$ for the $z=0$ shape of $p(\ln M_{\star,\rm BCG}\,|\,M_{\rm halo},z)$ and also that the fractional scatter in total stellar mass is below $10\%$ in halos more massive than $10^{14.3} M_{\odot}$

Caesarean Section among Referred and Self-Referred Birthing Women: A Cohort Study from a Tertiary Hospital, Northeastern Tanzania.

The inequity in emergency obstetric care access in Tanzania is unsatisfactory. Despite an existing national obstetric referral system, many birthing women bypass referring facilities and go directly to higher-level care centres. We wanted to compare Caesarean section (CS) rates among women formally referred to a tertiary care centre versus self-referred women, and to assess the effect of referral status on adverse outcomes after CS. We used data from 21,011 deliveries, drawn from the birth registry of a tertiary hospital in northeastern Tanzania, during 2000-07. Referral status was categorized as self-referred if the woman had bypassed or not accessed referral, or formally-referred if referred by a health worker. Because CS indications were insufficiently registered, we applied the Ten-Group Classification System to determine the CS rate by obstetric group and referral status. Associations between referral status and adverse outcomes after CS delivery were analysed using multiple regression models. Outcome measures were CS, maternal death, obstetric haemorrhage ≥ 750 mL, postpartum stay > 9 days, neonatal death, Apgar score < 7 at 5 min and neonatal ward transfer. Referral status contributed substantially to the CS rate, which was 55.0% in formally-referred and 26.9% in self-referred birthing women. In both groups, term nulliparous singleton cephalic pregnancies and women with previous scar(s) constituted two thirds of CS deliveries. Low Apgar score (adjusted OR 1.42, 95% CI 1.09-1.86) and neonatal ward transfer (adjusted OR 1.18, 95% CI 1.04-1.35) were significantly associated with formal referral. Early neonatal death rates after CS were 1.6% in babies of formally-referred versus 1.2% in babies of self-referred birthing women, a non-significant difference after adjusting for confounding factors (adjusted OR 1.37, 95% CI 0.87-2.16). Absolute neonatal death rates were > 2% after CS in breech, multiple gestation and preterm deliveries in both referral groups. Women referred for delivery had higher CS rates and poorer neonatal outcomes, suggesting that the formal referral system successfully identifies high-risk birth, although low volume suggests underutilization. High absolute rates of post-CS adverse outcomes among breech, multiple gestation and preterm deliveries suggest the need to target self-referred birthing women for earlier professional intrapartum care

Hybrid event bed character and distribution in the context of ancient deep‐lacustrine fan models

Hybrid event beds are texturally and compositionally-diverse deposits preserved within deepwater settings. They are deposited by flows exhibiting ‘mixed behaviour’, forming complex successions of sandstone and mudstone, which are often challenging to predict. Hybrid event beds are documented in deep-marine settings, where they have been thoroughly characterized, and are well-known as effective fluid transmissibility barriers and baffles in reservoirs. By comparison, there are far-fewer studies of hybrid event beds from deep-lacustrine settings, where their character and distribution remains relatively under-explored. In order to provide insights into these deposits, this study presents the detailed analysis of three-dimensional seismic data, wireline logs and core from a series of ancient deep-lacustrine fan systems in the North Falkland Basin. Results confirm that deep-lacustrine hybrid event beds comprise the same idealized sequence of the ‘H1–H5’ divisions. However, in this study H3 ‘debrite’ units can be sub-divided into ‘H3a–H3c’, based on: sharp or erosional intra-H3 contacts, bulk lithology, mud-content and discrete sedimentary textures. This study interprets the H3a–H3c sub-units as the products of multiple flow components formed through significant rearward longitudinal flow transformation processes, during the emplacement of a single hybrid event bed. Hybrid event beds are observed within lobe fringes, where flow types, energies, and transport mechanisms diversify as a result of flow transformation. The temporal context of hybrid event bed occurrences is considered in relation to stages of fan evolution, including: the Initiation; Growth (I); Growth (II); By-pass; Abandonment; and Termination phases. Hybrid event beds are mainly found in either the initiation phase where flow interaction and erosion of initial substrates promoted mixed flow behaviour, or in the abandonment phase as facies belt retreated landward. The results of this study have important implications in terms of flow processes of hybrid event bed emplacement, in particular sub-division of the H3 unit, as well as the prediction of hybrid event bed occurrence and character within ancient deep-lacustrine fan settings, in-general

Status and Potential of Single-cell Transcriptomics for Understanding Plant Development and Functional Biology

Funding Information University of Western Australia Acknowledgments The authors would like to extend sincere thanks to Robert Salomon for inspiring to write this manuscript. Resources were provided by The University of Western Australia.Peer reviewedPostprin

Clear lens phacoemulsification in the anterior lenticonus due to Alport Syndrome: two case reports

<p>Abstract</p> <p>Introduction</p> <p>Alport Syndrome has a prevalence of 1 case per 5,000 people and 85% of patients have the X-linked form, where affected males develop renal failure and usually have high-tone sensorineural deafness by age 20. The main abnormality is deficient synthesis of type IV collagen, the main component of basement membranes. Common ocular abnormalities of this syndrome consist of dot-and-fleck retinopathy, posterior polymorphous corneal dystrophy, and anterior lenticonus, but other ocular defects such as cataracts, posterior lenticonus, and retinal detachments have also been reported.</p> <p>Case presentation</p> <p>We report two cases of anterior lenticonus due to Alport Syndrome and describe clear lens phacoemulsification and foldable intraocular lens implantation as an effective and safe refractive procedure in the four eyes of these two patients.</p> <p>Conclusion</p> <p>All four eyes of the two patients were in good condition after surgery and achieved satisfactory optical and visual results and had no remarkable complications at six-months follow-up. Clear lens phacoemulsification with foldable intraocular lens implantation can be used as an efficient and safe procedure for vision disorders in these patients.</p

Carbon storage and DNA absorption in allophanic soils and paleosols

Andisols and andic paleosols dominated by the nanocrystalline mineral allophane sequester large amounts of carbon (C), attributable mainly to its chemical bonding with charged hydroxyl groups on the surface of allophane together with its physical protection in nanopores within and between allophane nanoaggregates. C near-edge X-ray absorption fine structure (NEXAFS) spectra for a New Zealand Andisol (Tirau series) showed that the organic matter (OM) mainly comprises quinonic, aromatic, aliphatic, and carboxylic C. In different buried horizons from several other Andisols, C contents varied but the C species were similar, attributable to pedogenic processes operating during developmental upbuilding, downward leaching, or both. The presence of OM in natural allophanic soils weakened the adsorption of DNA on clay; an adsorption isotherm experiment involving humic acid (HA) showed that HA-free synthetic allophane adsorbed seven times more DNA than HA-rich synthetic allophane. Phosphorus X-ray absorption near-edge structure (XANES) spectra for salmonsperm DNA and DNA-clay complexes indicated that DNA was bound to the allophane clay through the phosphate group, but it is not clear if DNA was chemically bound to the surface of the allophane or to OM, or both. We plan more experiments to investigate interactions among DNA, allophane (natural and synthetic), and OM. Because DNA shows a high affinity to allophane, we are studying the potential to reconstruct late Quaternary palaeoenvironments by attempting to extract and characterise ancient DNA from allophanic paleosol